Originally from Southeast Asia, the kratom (Mitragyna speciosa) tree can now be found as far afield as Papua New Guinea. Kratom, the Thai name for this plant, comes from the family Rubiaceae. Coffe and gardenia are two more well-known examples of the Rubiaceae family. In the United States, kratom has been used as a substitute for opiates in the treatment of withdrawal, chronic pain, and diarrhea. However, the FDA has raised concerns about toxicity and possible death with use of kratom, and there has been no clinical determination of its safety or effectiveness for these conditions. Its use is prohibited in a number of localities across the United States.
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