Cardiovascular Genetics and Genomics

By Dan M. Roden

The strategic driving force behind the American Heart Association's mission of healthier lives free of cardiovascular disease and stroke is to change practice by providing information and solutions to healthcare professionals. The books in the AHA Clinical Series focus on high-interest, cutting-edge topics in cardiovascular medicine and provide the latest information on the physiology, diagnosis, and management of a broad spectrum of conditions encountered in daily practice. Cardiovascular Genetics and Genomics Edited by Dan Roden, MD, Professor of Medicine and Pharmacology; Director, Oates Institute for Experimental Therapeutics; Assistant Vice-Chancellor for Personalized Medicine, Vanderbilt University School of Medicine, Nashville, Tenn, USA "The notion that risk for cardiovascular disease includes a genetic component has been ingrained into generations of practitioners ... We have been taught that these conditions often include a genetic component, and indeed if you ask, there is frequently a positive family history. As interesting as bedside observations ... might be, it has been very difficult to see how they made a whit of difference to the care of patients until the application of the tools of modern genetics and genomics began to unravel the disease genes and the underlying pathophysiologies." from the Preface This important volume outlines advances in gene discovery and describes how finding these genes might inform new approaches to practice. Under the careful editorial guidance of Dr. Roden, a team of expert contributors - including pioneers in genetics and genomics - help the cardiologist: Understand new technologies and terminologies Keep track of which genetic variants cause disease, predispose to disease, protect from disease, or predispose to variability in drug responses The book is divided into two main sections: "Principles" discusses varying approaches, statistical issues, and views of how this new knowledge will be incorporated into practice "Specific Cardiovascular Disease" reviews the current status of genetic and genomic knowledge in common cardiovascular diseases, with discussions of how genomic information may affect variability in drug responses An Appendix provides simple definitions to help the practitioner better make sense of the concepts. The data deluge launched by the human genome project presents astonishing opportunities and challenges. Cardiovascular Genetics and Genomics supplies a clear and thoughtful overview to help you maximize the opportunities for better patient care. Book jacket.

• Format: Hardcover
• Language: English
• ISBN: 1405175400
• ISBN13: 9781405175401
• Release Date: April 2009
• Publisher: Wiley-Blackwell
• Length: 288 Pages
• Weight: 1.40 lbs.
• Dimensions: 0.8" x 6.1" x 9.0"