Tumor-Induced Immune Suppression: Mechanisms and Therapeutic Reversal

By Dmitry I. Gabrilovich

Book Overview

This monograph, for the first time, presents a comprehensive overview of different mechanisms of immune dysfunction in cancer as well as therapeutic approaches to their correction. It discusses a number of new mechanisms that have never been discussed in a monograph before: T-cell inhibitory molecules, regulatory tolerogenic DCs, and signaling pathways in antigen-presenting cells involved in T-cell tolerance. The book addresses a pressing need to discuss the already described and newly emerging mechanisms to see how they can be put together in a more or less cohesive structure, and how they can help to improve immune response to tumors.

• Format: Paperback
• Language: English
• ISBN: 1441924000
• ISBN13: 9781441924001
• Release Date: October 2010
• Publisher: Springer
• Length: 302 Pages
• Weight: 0.97 lbs.
• Dimensions: 0.7" x 6.1" x 9.2"