The Science of Vaping: Chemistry, Toxicology, and Human Exposure

By Stephen Buss

The Science of Vaping

Chemistry, Toxicology and Human Exposure

Evidence-Based Harm Reduction: Volume I

Wordcount - 320,941

A substantial scientific foundation volume examining the chemistry, toxicology, exposure science, behavioural evidence and public controversies surrounding modern vaping and non-combustible nicotine products.

Modern nicotine products cannot be understood through headlines, assumptions or simplified comparisons. They require a detailed examination of combustion, aerosol science, formulation chemistry, flavour toxicology, analytical testing, human exposure and the behavioural realities of nicotine use.

The Science of Vaping provides a structured scientific evaluation of the physical, chemical and toxicological principles that separate combustible tobacco from non-combustible aerosol products. It examines the chemistry of combustion, the mechanisms of aerosol generation, the formation of carbonyls, the role of solvents, the behaviour of nicotine in different formulations, and the analytical methods used to measure emissions, impurities and exposure.

The book also considers the limits of current evidence. It addresses biomarkers, respiratory and cardiovascular research, cancer-related evidence, oral health, pregnancy, mental health, dual use and long-term uncertainty. Rather than treating vaping as either harmless or equivalent to smoking, it applies a weight-of-evidence approach grounded in dose, exposure, toxicological relevance and scientific uncertainty.

Across nine chapters, this volume examines the difference between hazard and risk, the importance of method validation, the difficulty of interpreting incomplete inhalation data, and the scientific controversies that have shaped public understanding of vaping, including formaldehyde, heavy metals, EVALI, passive exposure, youth uptake and the gateway hypothesis.

This is not a promotional account of vaping. It is a scientific foundation for understanding modern nicotine products, written for readers who want to move beyond slogans and examine the chemistry, toxicology and exposure science on which credible harm reduction must depend.

• Format: Hardcover
• Language: English
• ISBN: 1919456759
• ISBN13: 9781919456751
• Release Date: August 2026
• Publisher: Ragequitremedy Ltd Publishing Press
• Length: 808 Pages
• Weight: 3.57 lbs.
• Dimensions: 2.3" x 6.0" x 9.0"