The first cousins and best friends are bound by more than genetics. Though glib and impulsive, Michael's brilliant ghostwriting masks Sarah's learning disabilities, while alluring and perceptive Sarah helps Michael through his perpetually awkward phase with women. The two pursue individual success, both with and in spite of each other.
For Sarah and Michael, their ancestors' memories offer a cryptic roadmap that leads them on a worldwide odyssey revealing tantalizing truths about the earth's ancient history and life's earliest evolution. Sarah embarks on a quest to unlock these secrets, convinced that it will provide her with scientific proof that humankind is destroying itself and the planet with reckless genetic engineering.