Stabilization of drug nanocrystals using fibroin: Formulation & evaluation of drug nanocrystal and stabilize using fibroin

By Rani Dhole, Neha Desai, Jyoti Admuthe

Nanocrystals of the poorly water-soluble drugs is a promising strategy. To stabilize the drug nanocrystals, stabilizers are usually used; however, the use of common stabilizers is limited by weak stabilization effect and toxicological concerns for long-term treatment. The present work was aimed to investigate the potential of natural silk protein as novel stabilizer for nanocrystal of hydrochlorothiazide, which was a model drug. The nanocrystals of drug with hydrophobic protein stabilizer were prepared by antisolvent precipitation method.Prepared nanocrystals were evaluated for parameters like particle size, zeta potential, DSC, XRD, %crystallinity, SEM, drug content and in vitro dissolution test. Stabilization efficiency of nanocrystals was assessed by their % crystallinity for 3 months. Optimized batch R2 has shown smaller particle size, highest drug content and drug dissolution. Nanocrystals has shown the extended release due to coat of fibroin around the hydrochlorothiazide. From the % crystallinity study it was found that there was not significant change in the nanocrystals prepared using fibroin. So, it was concluded that the fibroin is good stabilizer for drug nanocrystals.

• Format: Paperback
• Language: English
• ISBN: 6202515090
• ISBN13: 9786202515092
• Release Date: March 2020
• Publisher: LAP Lambert Academic Publishing
• Length: 112 Pages
• Weight: 0.39 lbs.
• Dimensions: 0.3" x 6.0" x 9.0"