Sickle cell disease (SCD) is a life-threatening genetic disorder that affects the red blood cells (RBCs). People with SCD have a mutation in the gene that codes for the SCD protein. This protein helps the RBCs to deform and travel through the blood vessels. SCD is caused by a change in the DNA sequence of one of the gene's DNA symbols. The mutation can occur randomly in any person or in families. SCD is most common in people of African descent. SCD is a serious medical condition and can cause death in severe cases. In most cases, SCD can be managed with regular blood transfusions and treatment with medications. About 1 in 500 people in the United States have SCD. SCD is also known as hemoglobin S, hemoglobin C, α-thalassemia, and α-thalassemias. Target audience [GENERAL]SCD is a life-threatening genetic disorder that affects the red blood cells (RBCs). People with SCD have a mutation in the gene that codes for the SCD protein. This protein helps the RBCs to deform and travel through the blood vessels. SCD is caused by a change in the DNA sequence of one of the gene's DNA symbols. The mutation can occur randomly in any person or in families. SCD is most common in people of African descent. SCD is a serious medical condition and can cause death in severe cases. In most cases, SCD can be managed with regular blood transfusions and treatment with medications. About 1 in 500 people in the United States have SCD. SCD is also known as hemoglobin S, hemoglobin C, α-thalassemia, and α-thalassemias.
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