Protein-Ligand Interactions

By Holger Gohlke

Innovative and forward-looking, this volume focuses on recent achievements in this rapidly progressing field and looks at future potential for development. The first part provides a basic understanding of the factors governing protein-ligand interactions, followed by a comparison of key experimental methods (calorimetry, surface plasmon resonance, NMR) used in generating interaction data. The second half of the book is devoted to insilico methods of modeling and predicting molecular recognition and binding, ranging from first principles-based to approximate ones. Here, as elsewhere in the book, emphasis is placed on novel approaches and recent improvements to established methods. The final part looks at unresolved challenges, and the strategies to address them. With the content relevant for all drug classes and therapeutic fields, this is an inspiring and often-consulted guide to the complexity of protein-ligand interaction modeling and analysis for both novices and experts.

• Format: Hardcover
• Language: English
• ISBN: 3527329668
• ISBN13: 9783527329663
• Release Date: May 2012
• Publisher: Wiley-Vch
• Length: 359 Pages
• Weight: 1.80 lbs.
• Dimensions: 0.9" x 6.9" x 9.7"