This revised textbook examines the most important aspects of multiple sclerosis that impact on clinical trial design, on the development of new disease therapies, and, very importantly, on patient care. The international team of contrib4tors discusses the clinical course of multiple sclerosis, its clinical heterogeneity, and the presence of subclinical disease activity that occurs during the early stages of the disease. There have been substantial advances in the field since the first edition was published in 1999. The previous chapters have been updated to reflect these new findings, and several new chapters have been added. Multiple sclerosis presents substantial clinical challenges, from unexpected and irregular relapses to progressive deterioration. The reader will find help with these challenges in Multiple Sclerosis Therapeutics (Second edition).
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