Mortalin Biology: Life, Stress and Death

By Sunil C. Kaul and Wadhwa Renu

Book Overview

Contributors.- Foreword.- Preface.- Section 1: Structure and Function of Mortalin.- 1. Birth of Mortalin: Multiple Names, Niches and Functions Connecting Stress, Senescence and Cancer.- 2. Mortalin's Machinery.- 3. The Role of Mortalin in Iron Homeostasis .- 4. Functional Characteristics of Mortalin.- Section 2: Mortalin in Evolution2 Deocaris.- 5. Mortalin and Drosophila DmHsp22: Two Mitochondrial Chaperones Regulating Aging and Carcinogenesis .- 6. Mortalin in Invertebrates and The Induction of Apoptosis by Wild-Type p53 Following Defeat of Mortalin-Based Cytoplasmic Sequestration in Cancerous Clam Hemocytes .- 7. Mortalin and Stem Cells: A Study from Planarians.- Section 3: Mortalin in Health and Disease.- 8. Mortalin in Cell Protection from Immune Attack .- 9. Mortalin in Neurological Diseases.- 10. Loss of Mortalin Function in Parkinson's Disease - Supporting the Mitochondrial Pathway of Neurodegeneration.- 11. Hsp75/mortalin and Protection from Ischemic Brain Injury.- 12. Catecholamine Regulated Protein (CRP40), A Splice Variant of Mortalin-2: Functional Role in CNS Disorders.- 13. Chaperonopathies: Diseases in Which Mortalin and Other Hsp-Chaperones Play a Role in Etiology and Pathogenesis.- Section 4: Mortalin and Cancer.- 14. The Many Faces of Mortalin and Tid1.- 15. Mortalin: A Positive Regulator of Centrosome Duplication and Amplification.- 16. Mortalin Expression in Normal and Neoplastic Tissues .- 17. Mortalin - p53 Interaction as A Target for Liver Cancer Therapy.- 18. Mortalin Targeting Gadgets for Cancer Therapy.- Section 5: Mortalin Based Technologies.- 19. Cell Internalizing Anti-Mortalin Antibody for Generation of Illuminating MSCs for Long-Term in vitro and in vivo Tracking.- 20. Mortalin Staining Pattern as A Reporter for Cell Based Anti-Cancer Drug Screening.- 21. Cell Internalizing Anti-Mortalin Antibody as a Nanocarrier.

• Format: Paperback
• Language: English
• ISBN: 9401782792
• ISBN13: 9789401782791
• Release Date: April 2014
• Publisher: Springer
• Length: 342 Pages
• Weight: 1.10 lbs.
• Dimensions: 0.8" x 6.0" x 9.0"