Molecular Machines Involved in Peroxisome Biogenesis and Maintenance

By Cecile Brocard

Book Overview

Peroxisome biogenesis and function: History and Discovery of peroxins.- Human cell lines to study peroxisome biogenesis.- Mouse models to study peroxisome biogenesis.- Metabolic interaction between peroxisome and Mitochondria.- Peroxisomal Diseases: The Zellweger spectrum.- Molecular basis.- PEX11beta.- Peroxisome morphology in pathologies.- Other peroxisome-related disorders.- New technologies applied to study peroxisomes: Bioinformatics.- Imaging in plant and peroxules.- Tools to study peroxisomes as signaling platform: oxidative stress studies and antiviral innate immunity.- Proteomic approach. Protein transport across the peroxisomal membrane: The matrix protein import complex in yeast.- Protein transport in plant peroxisomes.- Concept Exportomer.- Factors involved in ubiquitination/deubiquitination of PEX5.- Peroxisome dynamics: Trafficking of the peroxisome biogenesis factor PEX3 through the ER.- Role of PEX3 and PEX19 in peroxisome membrane biogenesis.- Vesicles, reticulon and ER-to-peroxisome contact sites.- Pex11 proteins and their alpha-helix.- Molecular complex coordinating peroxisome morphogenesis.- Dynamin-related proteins. Specific degradation through pexophagy: Principle of selective organelle degradation: Factors involved in pexophagy in the yeast Pichia pastori

• Format: Paperback
• Language: English
• ISBN: 3709119820
• ISBN13: 9783709119822
• Release Date: September 2016
• Publisher: Springer
• Length: 543 Pages
• Weight: 1.71 lbs.
• Dimensions: 1.1" x 6.1" x 9.3"