Mitochondrial Genetics and Cancer

By Gabriel D. Dakubo

Book Overview

PART 1: GENERAL OVERVIEW OF MITOCHONDRIAL GENETICS AND FUNCTIONS 1. Basic Mitochondrial Genetics, Bioenergetics and Biogenesis 2. The Warburg Phenomenon and Other Metabolic Alterations of Cancer Cells 3. Mitochondrial Control of Apoptosis and Cancer 4. Mitochondrial-to-Nuclear Communications in Cancer PART 2: MITOCHONDRIAL GENETIC ALTERATIONS IN CANCER 5. Types of Mitochondrial Genetic Alterations in Cancer 6. Mitochondrial Genetic Alterations in Cancer I: Skin, Head and Neck, 7. Mitochondrial Genetic Alterations in Cancer II: Renal, Urinary Bladder, Prostate, Ovarian, Endometrial, Cervical, Nervous System, Hematologic, and Connective Tissue Cancers 8. Mitochondrial Genome Rearrangements and Copy Number Changes in Cancer 9. Functional Importance of Mitochondrial Genetic Alterations in Cancer 10. The Role of Mitochondrial Reactive Oxygen Species in Cancer PART 3: CLINICAL APPLICATIONS OF MITOCHONDRIAL GENOME CHANGES IN CANCER 11. Mitochondrial DNA Measurement in Exfoliated Cells for Cancer Detection and Monitoring - the Copy Number Advantage 12. Early Cancer Detection and Monitoring Using Changes in the Mitochondrial Genome as Biosensors 13. Analysis of Mitochondrial Genome Alterations in Cancer 14. "Mitocans" Agents Targeting Mitochondrial to Kill Cancer Cells

• Format: Paperback
• Language: English
• ISBN: 3642424619
• ISBN13: 9783642424618
• Release Date: November 2014
• Publisher: Springer
• Length: 356 Pages
• Weight: 1.15 lbs.
• Dimensions: 0.8" x 6.1" x 9.2"