Human Monoclonal Antibodies: Methods and Protocols

Book Overview

1. Human Monoclonal Antibodies - The Residual Challenge of Antibody Immunogenicity

Herman Waldmann

2. Technical and Ethical Limitations in Making Human Monoclonal Antibodies

Mark C. Glassy and Rishab Gupta

3. Therapeutic Human Monoclonal Antibodies in Inflammatory Diseases

Sotirios Kotsovilis and Evangelos Andreakos

4. Therapeutic Human Monoclonal Antibodies Against Cancer

Jamie Jarboe, Anumeha Gupta, and Wasif Saif

5. Polyclonal and Monoclonal Antibodies in the Clinic

Bharath Wootla, Aleksandar Denic, and Moses Rodriguez

6. Production of Human Monoclonal Antibodies by the Epstein- Barr Virus Method

Michael Steinitz

7. Humanization and Simultaneous Optimization of Monoclonal Antibody

T. Kuramochi, T., Igawa, H. Tsunoda, and K. Hattori

8. Chimeric Antibodies

Kohei Kurosawa, Waka Lin, and Kunihiro Ohta

9. Recombinant Genetic Libraries and Human Monoclonal Antibodies

Jarrett J. Adams, Bryce Nelson, and Sachdev S. Sidhu

10. Production of Stabilized scFv Antibody Fragments in the E. coli Bacterial Cytoplasm

Lilach Vaks and Itai Benhar

11. Construction and Production of an IgG-Like Tetravalent Bispecific Antibody, IgG-Single Chain Fv Fusion

Dan Lu and Zhenping Zhu

12. Construction of Human Antibody Gene Libraries and Selection of Antibodies by Phage Display

Andr? Frenzel, Jonas K?gler, Sonja Wilke, Thomas Schirrmann, and Michael Hust

13. Antigen -Specific Human Monoclonal Antibodies from Transgenic Mice

Susana Magad?n Momp? and ?frica Gonz?lez-Fern?ndez

14. Phage Display Technology for Human Monoclonal Antibodies

Cecilia Deantonio, Diego Cotella, Paolo Macor, Claudio Santoro, and Daniele Sblattero

15. Antigen-Specific in vitro Immunization: A Source for Human Monoclonal Antibodies

Kosuke Tomimatsu and Sanetaka Shirahata

16. Methods for Radiolabelling of Monoclonal Antibodies

Vladimir Tolmachev, Anna Orlova, and Karl Andersson

17. Purification of Human Monoclonal Antibodies and Their Fragments

Thomas Muller-Sp?th and Massimo Morbidelli

18. Idiotype-Specific IVIG for Therapy of Autoimmune Diseases

Tomer Bashi, Miri Blank, and Yehuda Shoenfeld

• Format: Paperback
• Language: English
• ISBN: 1493960199
• ISBN13: 9781493960194
• Release Date: August 2016
• Publisher: Humana
• Length: 364 Pages
• Weight: 1.45 lbs.
• Dimensions: 0.8" x 7.0" x 10.0"