Genome-Scale Algorithm Design

By Fabio Cunial, Alexandru I. Tomescu, Veli Mäkinen, et al.

Presenting the fundamental algorithms and data structures that power bioinformatics workflows, this book covers a range of topics from the foundations of sequence analysis (alignments and hidden Markov models) to classical index structures (k-mer indexes, suffix arrays, and suffix trees), Burrows-Wheeler indexes, graph algorithms, network flows, and a number of advanced omics applications. The chapters feature numerous examples, algorithm visualizations, and exercises, providing graduate students, researchers, and practitioners with a powerful algorithmic toolkit for the applications of high-throughput sequencing. An accompanying website (www.genome-scale.info) offers supporting teaching material. The second edition strengthens the toolkit by covering minimizers and other advanced data structures and their use in emerging pangenomics approaches.

• Format: Hardcover
• Language: English
• ISBN: 1009341235
• ISBN13: 9781009341233
• Release Date: October 2023
• Publisher: Cambridge University Press
• Length: 470 Pages
• Weight: 2.08 lbs.
• Dimensions: 1.0" x 6.7" x 9.6"