Fatty Acid and Lipotoxicity in Obesity and Diabetes

by Jamie A. Goode and Gregory Bock

The potential lipotoxic effect of accumulation of fatty acids in non-adipose tissues is thought to be a major component in the development of insulin resistance. Chronic exposure to high concentrations of free fatty acids in the blood affects pancreatic β cell function, insulin secretion and lipid synthesis in the liver, and storage in adipose tissue. Maintaining the normal levels of fatty acids requires coordinated regulation between the liver,...

• Format: Hardcover
• Language: English
• ISBN: 0470057645
• ISBN13: 9780470057643
• Release Date: January 2008
• Publisher: Wiley
• Length: 222 Pages
• Weight: 1.06 lbs.
• Dimensions: 0.6" x 6.4" x 9.3"