Asthma is a disease whose presence dates back to the time of Hippocrates, 'the father of medicine', who noted a condition of "deep and heavy breathing". The Greeks named it ASTHMA, which means "breathless". It is a common chronic disorder of the airways that involves a complex interaction of airflow obstruction, bronchial hyperresponsiveness, and underlying inflammation. The dominant physiological event leading to clinical symptoms of airway narrowing and subsequent interference with airflow (bronchoconstriction) occurs in response to exposure to a variety of stimuli including allergens or irritants. Allergen-induced acute bronchoconstriction results from an IgE-dependent release of mediators from mast cells that includes histamine, tryptase, leukotrienes, and prostaglandins that directly contract airway smooth muscle. Although bronchial asthma starts with bronchoconstriction there are varying degrees of airway inflammation in every patient with asthma. Airway inflammation is persistent even though symptoms are episodic but the relationship between the severity of asthma and the intensity of inflammation is not clearly established. The pattern of inflammation in the airways appears to be similar in all clinical forms of asthma.
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