Clinical depression is a debilitating mood disorder which negatively impacts one's productivity leading to the burden of disability that requires treatment to promote recovery and prevent relapses. To date, there exists a range of diverse treatment interventions for depressive disorder to reduce its negative outcomes on the health and daily functioning of individuals. The etiology of depression is as varied and multifaceted as symptom clusters themselves. Nevertheless, a grand unifying theory addressing the full spectrum of this disorder is as elusive as a comprehensive standard line of treatment. Are research and clinical strategies missing the mark in their various discrete approaches? This book is a brief exploration of various frontiers in the neuropsychosocial spectrum of a condition that is diverse and at times, resistant to all possible options of treatment, covering the significance of causality, homeostatic balance, temporal factors and sociocultural determinants.
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