Bioavailability of itraconazole formulation influence of nature of diet

By Anil Kumar Patni

administered shortly after a meal. The nutrient and calorie contents of the meal, the meal

volume and the meal temperature can cause physiological changes in the gastrointestinal tract

in a way that affects drug product transit time, luminal dissolution, drug permeability and

systemic availability. In general, meals that are high in calorie and fat content are more

likely to affect gastrointestinal physiology and thereby, result in a larger effect

on the bioavailability of a drug

substance.

There are several reviews on the effects of food on the pharmacokinetics of

drugs (Karim., 1996, Welling., 1996, Fleisher et al., 1999, Singh., 1999). Interactions

between food and drugs can unintentionally reduce or increase the effect of the drug, resulting

in

therapeutic failure or increased toxicity.

• Format: Paperback
• Language: English
• ISBN: B09Y14L856
• ISBN13: 9798210202062
• Release Date: April 2022
• Publisher: Department of Pharmaceutical Sciences & Drug
• Length: 252 Pages
• Weight: 0.75 lbs.
• Dimensions: 0.5" x 6.0" x 9.0"