A Silent Threat: Exploring New Therapies for Abdominal Aortic Aneurysms

By Mackil

Fibronectin (FN) is a component of the interstitial ECM. It also mediates cell attachment and function 16]. It is a fibril-forming glycoprotein which is structurally a dimer of two identical proteins of 250 kDa covalently attached via disulfide bonds at their C termini. It is ubiquitously expressed in tissues. Different functional motifs on its structure helps fibronectin to interact with GAGs, collagens, fibrin and integrins facilitating matrix organization and cell-matrix interactions 18]. For example, fibronectin serves as a template for proper collagen fibrillogenesis by forming a fibril network engaged by cell surface integrins 16]. Cellular traction force causes FN to be stretched several times over its resting length 18]. As a result of such stretching, cryptic integrin-binding sites within the FN molecule is exposed resulting in pleiotropic changes in cellular behavior 18]. Hence FN acts as an extracellular mechano-regulator in addition to its role in cell migration during development. Studies have also shown the implication of FN in cardiovascular diseases and tumor metastasis

• Format: Paperback
• Language: English
• ISBN: 3384280075
• ISBN13: 9783384280077
• Release Date: July 2024
• Publisher: Tredition Gmbh
• Length: 206 Pages
• Weight: 0.68 lbs.
• Dimensions: 0.5" x 6.0" x 9.0"