Zinc is an indispensable trace element that underpins cellular function, metabolic balance, and systemic health. Its biological significance extends from molecular signaling and enzymatic activity to immune regulation and organ integrity. This book examines the cellular foundations of zinc biology, including micro-deficiencies, global prevalence, zinc transport systems (ZIPs and ZnTs), mechanisms of absorption and circulation, physiological homeostasis, and adaptive responses to deficiency. It further explores the clinical consequences of zinc imbalance, addressing its roles in inflammation, glucose metabolism, neuroinflammatory disorders, tumorigenesis, chronic kidney disease, and vascular calcification. This book provides a translational framework linking zinc homeostasis to disease mechanisms and therapeutic perspectives.
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