The first edition of this handbook, published in 2012, provided general guidance on the steps involved in guideline development and on GRC and WHO processes and procedures. This second edition provides additional detailed guidance on each step in guideline development, as well as two additional chapters. Chapter 5 deals with the importance of considering equity, human rights, gender and the social determinants of health in formulating recommendations. The chapter provides specific entry points for integrating these issues into each and every guideline developed by WHO. Chapter 11 describes the development of rapid advice guidelines in the context of a public health emergency, with a focus on how the standard methods of evidence review and synthesis need to be modified to produce such guidelines. This handbook provides step-by-step guidance on how to plan, develop and publish a World Health Organization (WHO) guideline. It covers the methods, processes and procedures for producing a document that meets WHO standards. It does not provide detailed technical guidance on many of the steps: this can be obtained from the references in the handbook and through references to the published scientific literature listed on WHO's Guideline Review Committee (GRC) intranet site (available to WHO staff). Additional chapters of this handbook containing detailed guidance on selected topics are also available and new chapters will continue to be added to the GRC intranet site in response to the needs of WHO guideline developers.
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