In the 1950s, an unusual alliance of vampires, witches and humans worked together to imprison a master vampire, Von Damme, and his radical followers in beneath the waters of the South Holston Lake, Tennessee. Decades later, the superior vampires and their zealots have escaped and formed the Devils Horns. The gang of cosplay-loving and supernatural bikers terrorize the twin towns of Bristol while seeking revenge for the building of the dam long ago. They sic supernatural catamounts upon everyone's beloved fur babies, transforming them into fate worse than death, and unleash a pack of bloodthirsty werewolves to run amok through the streets, hills and hollows of Appalachia. The blood brothers, those who destroyed Von Damme last summer, are the targets of shadowy assassins. The crew of reality TV show The Myth Huntress returns to the ruins of the mansion where they face a new supernatural threat. Sullivan County Deputy Marge, the leader of the new task force on the supernatural, begins the hunt for a pair of kidnapped girls and soon confronts the truth that vampires are trying to kill her. A modern-day paladin, a 13th Son of Galahad, searches for why werewolves are congregating in Bristol and working with vampires instead of protecting people from them. In the overcrowded hospital, fear is contagious, and ER doctor with synesthesia must deal with what is feasting on the frightened staff and patients in the gloomy days before Halloween. The gorgeous vampire, Elke, holds the secret of the Devil-faced jars. Her consort, Dillon, seeks the truth behind the funk from the dump and what's hidden in the landfill, where the cult, the Butcher pack, and the Devils Horns gather to enact the vengeance of the vampires.