Under Hyperglycemic Hepatotoxicity

By Shekhar S

Redox Homeostasis in Hyperglycemic Hepatotoxicity, written by Vivek Kumar, is an insightful book that explores the complex relationship between redox homeostasis, hyperglycemia, and hepatotoxicity. The book delves into the various mechanisms through which hyperglycemia induces oxidative stress and disrupts the antioxidant defense system of the liver, leading to lipid peroxidation, advanced glycation end products, and protein carbonylation. The author highlights the role of various key molecules and pathways involved in redox homeostasis, such as glutathione, Nrf2, Keap1, and the electron transport chain of mitochondria. The book also explores the links between hyperglycemia, insulin resistance, and the development of fatty liver, non-alcoholic fatty liver disease, and non-alcoholic steatohepatitis. In addition, the book covers the molecular mechanisms involved in the induction of inflammation, cytokines, chemokines, and nuclear factor-kappaB signaling, as well as various signaling pathways, such as MAPK, PI3K/Akt, AMPK, and mTOR, that play a crucial role in regulating redox homeostasis in the liver. Furthermore, the book discusses the role of various cell death mechanisms, including apoptosis, necroptosis, ferroptosis, and mitophagy, in hyperglycemic hepatotoxicity. The author also examines the influence of epigenetics, microRNAs, and the gut-liver axis on redox homeostasis. Finally, the book delves into the potential of various nutraceuticals, phytochemicals, prebiotics, probiotics, and synbiotics to modulate redox homeostasis and improve liver health. Overall, Redox Homeostasis in Hyperglycemic Hepatotoxicity is an essential resource for researchers and clinicians interested in understanding the complex interplay between redox homeostasis, hyperglycemia, and liver health.

• Format: Paperback
• Language: English
• ISBN: B0CKTZFDDV
• ISBN13: 9798889954255
• Release Date: September 2023
• Publisher: Self Publisher
• Length: 228 Pages
• Weight: 0.68 lbs.
• Dimensions: 0.5" x 6.0" x 9.0"