Tyrosine Phosphorylation/Dephosphorylation and Downstream Signalling

By Ludwig M.G. Heilmeyer Jr.

Book Overview

Nearly every cellular activity, such as cell growth,proliferation, protein synthesis, and nuclear division, isregulated by protein phosphorylation/dephosphorylation ontyrosine residues as initiation events.Synchronizationoccurs through interaction of protein tyrosine kinases andphosphatases.This book unveils signal pathways that connectextracellular signals with changes of phosphorylation stateof target proteins allowing coordinated and integratedmodulation of mitogenic signalling. Specifically, cascadesinvolving protein serine/threonine kinases and connectionsto phosphoinositides derived second messengers arediscussed.

• Format: Paperback
• Language: English
• ISBN: 3642782493
• ISBN13: 9783642782497
• Release Date: December 2011
• Publisher: Springer
• Length: 376 Pages
• Weight: 1.22 lbs.
• Dimensions: 0.8" x 6.1" x 9.2"