Preface. Chapter 1. Effect of chemotherapy on the tumor microenvironment and anti-tumor immunity. Chapter 2. Hyperthermia, the tumor microenvironment and immunity. Chapter 3. Radiofrequency Ablation in Cancer Therapy: Tuning in to in situ tumor vaccines. Chapter 4. High Intensity Focused Ultrasound (HIFU) Ablation. Chapter 5. The interrelationship between cryoablation the immune Response and the tumor microenvironment: Stimulatory and Suppressive Effects. Chapter 6. In situ tumor ablation with radiation therapy - its effect on the tumor microenvironment and anti-tumor immunity. Chapter 7. Tumor-localized insult delivered by photodynamic therapy and the breakdown of tumor immunotolerance. Chapter 8. Effect of electric based ablation treatments on the tumor microenvironment and anti-tumor immunity. Index.