Transforming Growth Factor-Beta in Cancer Therapy, Volume I: Basic and Clinical Biology

By Michael B. Sporn

Transforming Growth Factor-jl in Cancer Therapy, Volume I: Basicand Clinical Biology The present volume brings together a wealth of information that is fundamental to understanding the roleofTGF- in the pathogenesis, prevention, and treatment of cancer. It is not even 25 years sinceTGF- was first isolated and characterized as a dimeric pep- tide from both human and bovine sources (1-3), but the entire fieldofTGF- research has grown and expanded so that it is now a central theme in all of cell biology. There is almost no tissue or organ in the mammalian body in whichTGF- does not playa central role in embryonic differentiation or in adult function, and furthermore, malfunction of the normal physiologyofTGF- can have disastrous consequences in almost all ofthese sites. Therefore, the present comprehensive review of so many aspects ofTGF- function is a most welcome attempt to bring together a huge body of experimental data that is of the utmost importance in the field of oncology.

• Format: Paperback
• Language: English
• ISBN: 161737735X
• ISBN13: 9781617377358
• Release Date: November 2010
• Publisher: Humana
• Length: 735 Pages
• Weight: 2.85 lbs.
• Dimensions: 1.5" x 7.0" x 10.0"