
Protein Cooperativity and Wrapping: Two Themes in the Transformative Platform of Molecular Targeted Therapy.- Wrapping Defects and the Architecture of Soluble Proteins.- Folding Cooperativity and the Wrapping of Intermediate States of Soluble Natural Proteins.- Wrapping Deficiencies...


In spite of the enticing promises of the post-genomic era, the pharmaceutical world is in a state of disarray. Drug discovery seems now riskier and more uncertain than ever. Thus, projects get routinely terminated in mid-stage clinical trials, new targets are getting harder to...