Tubulin-Binding Agents: Synthetic, Structural and Mechanistic Insights

Book Overview

Macrolide-Based Microtubule-Stabilizing Agents - Chemistry and Structure-Activity Relationships.- The Chemical Synthesis of Discodermolide.- The Interaction of Microtubules with Stabilizers Characterized at Biochemical and Structural Levels.- The Tubulin Binding Mode of MT Stabilizing and Destabilizing Agents Studied by NMR.- The Tubulin Binding Mode of Microtubule Stabilizing Agents Studied by Electron Crystallography.- Microtubule-Destabilizing Agents: Structural and Mechanistic Insights from the Interaction of Colchicine and Vinblastine with Tubulin.- Molecular Modeling Approaches to Study the Binding Mode on Tubulin of Microtubule Destabilizing and Stabilizing Agents.

• Format: Paperback
• Language: English
• ISBN: 3642435947
• ISBN13: 9783642435942
• Release Date: November 2014
• Publisher: Springer
• Length: 331 Pages
• Weight: 1.06 lbs.
• Dimensions: 0.7" x 6.1" x 9.2"