Titanium Dioxide

By Dakshayani Lomada, Madhava C. Reddy, Surendra Gulla

This book describes the role of titanium dioxide nanotubes conjugated with quercetin in skin cancer and inflammation. TNT-Quercetin are human safe, cost effective and stable chemical with numerous biomedical applications. The authors of this book developed a novel drug combinational molecule by conjugating TNT with quercetin. The authors found the enhanced anti-cancer activity of TNT-Qu by inducing apoptosis and cell cycle arrest at the G2/M phase in B16F10 cells. Furthermore, TNT-Qu treatment up-regulated cleaved caspase-3 expression in B16F10 cells. More importantly, the in-vivo data demonstrated that TNT-Qu treatment inhibited the growth and metastasis of skin tumors significantly by down-regulating the pSTAT3 expression and restoring γδ T cell population when compared to TNT or quercetin alone treatment. Taken together, the in-vitro and in-vivo data strongly suggest that TNT-Qu could be a novel combinational therapeutic agent for the treatment of skin cancer.

• Format: Paperback
• Language: English
• ISBN: 620614416X
• ISBN13: 9786206144168
• Release Date: February 2023
• Publisher: LAP Lambert Academic Publishing
• Length: 136 Pages
• Weight: 0.46 lbs.
• Dimensions: 0.3" x 6.0" x 9.0"