Tissue engineering in endodontics aims to restore the vitality and function of the pulp-dentin complex rather than merely replacing damaged tissues. It integrates stem cells, growth factors, bioactive signaling molecules, and biocompatible scaffolds to promote pulp regeneration. Scaffold design is critical, as it provides structural support, facilitates cell attachment, proliferation, differentiation, and vascularization, and enables the controlled release of growth factors. Advances in natural, synthetic, and composite scaffold materials have significantly enhanced the potential for predictable and successful regenerative endodontic therapy.
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