Charlotte Ambrose has been suffering from a mysterious disease since childhood. Now, 44 years old and multiple surgeries later, she is admitted to St. John's Hospital with an unbearable migraine headache. Fortunately, a famous geneticist takes over her case, and Charlotte has the rare hope of, if not a cure, at least the identification of this disease.
But while in the hospital under the care of the geneticist and her team, even worse things begin to affect Charlotte's health. Strange, nearly fatal events begin to threaten Charlotte's life as well as the lives of her medical team. Finally, there is indeed an unexplained and horrifying death.