The Smoothened Receptor in Cancer and Regenerative Medicine

Book Overview

Canonical and non canonical Hedgehog signaling pathways, coupling to G-proteins.- Pharmacochemistry of the Smoothened receptor: Agonists, antagonists, allosteric modulators.- Receptor modifications in Hedgehog regulation.- Smoothened, stem cell maintenance and brain diseases.- Medulloblastoma, pediatric brain tumors and Smoothened blockade.- Role of Smoothened and Hedgehog signaling in angiogenesis, neovascularization.- Implications in stem cell maintenance.- Comparison of the crystal structure of Smoothened to known GPCRs structure.

• Format: Paperback
• Language: English
• ISBN: 3319354027
• ISBN13: 9783319354026
• Release Date: October 2016
• Publisher: Springer
• Length: 210 Pages
• Weight: 0.69 lbs.
• Dimensions: 0.5" x 6.1" x 9.2"