The novel follows Edgar Allen, a palliative-care doctor who dies suddenly and is secretly chosen as the subject of a revolutionary experiment. Driven by billionaire entrepreneur Jeffrey Abel and led by scientist Eloise Deuss, a research team succeeds in achieving what humanity has long considered impossible: the resurrection of a dead human being. However, the triumph quickly turns into a nightmare. Edgar returns physically alive but mentally devastated, stripped of his memories, language, and personality. To make matters worse, the experiment was performed without his consent after Abel illegally obtained his body, creating a profound ethical crisis.
As Eloise struggles with guilt and responsibility, she attempts to rehabilitate Edgar while concealing the truth from her junior colleagues, Anna Gilman and Chaucer Szondi. Abel, meanwhile, sees resurrection not as a scientific breakthrough but as a commercial opportunity. He dreams of conquering death, monetizing immortality, and ultimately gaining the power to recover those he has lost. When Edgar's damaged condition threatens those ambitions, Abel proposes eliminating him and starting over with a new subject.
Gradually, Edgar regains awareness and intelligence. Yet the man who emerges is not the same person who died. His resurrection has fundamentally altered him. Detached from ordinary human emotions and increasingly convinced that he no longer belongs to the human race, he begins to investigate the circumstances of his death, his marriage, and the experiment that violated his autonomy. At the same time, a parallel storyline follows Detective Chief Inspector Angelica Bastion and Sergeant David Bruns as they investigate a series of mysterious deaths connected to Edgar's disappearance.
The novel alternates between Edgar's present-day conversations with Wilbur Scoville, a blind elderly man to whom he recounts his extraordinary story, and the unfolding events that led to his transformation. As Edgar uncovers painful truths about the people around him, his search for justice becomes increasingly dark and violent. Jeffrey Abel is murdered, suspicion falls on Edgar, and the police struggle to determine whether the seemingly impossible claims of resurrection could actually be true.
Ultimately, Edgar discovers that resurrection has come at a terrible price. His body is biologically unstable and slowly deteriorating. Realizing that he is dying once again and convinced that the experiment must never be repeated, he confronts those responsible. In a tragic climax, he kills Anna during a confrontation before collapsing and dying permanently. His death brings an end to the first successful resurrection of a human being and leaves behind unanswered questions about whether humanity should ever possess such power.
Blending scientific speculation with crime fiction and existential reflection, The River and the Sea examines whether defeating death is truly a victory. Through Edgar's journey, the novel argues that life, death, memory, identity, and morality are inseparable, and that crossing the boundary between life and death may create consequences far beyond human understanding.