The Nematode Caenorhabditis Elegans: (Cold Spring Harbor Monograph Series 17)

By William B. Wood

Book Overview

In 1965 Sydney Brenner chose the free-living nematode Caenorhabditis elegans as a promising model system for a concerted genetic, ultrastructural, and behavioral attack on the development and function of a simple nervous system. Since then, with the help of a growing number of investigators, knowledge about the biology of "the worm" has accumulated at a steadily accelerating pace to the extent that C. elegans is now probably the most completely understood metazoan in terms of anatomy, genetics, development, and behavior. The past few years have seen the completion of two major long-term projects that provide new insights into C. elegans development and lay important groundwork for future investigation: completion of the cell lineages of both sexes, from zygote to adult, and description of the complete anatomy at the level of electron microscope resolution, providing a complete "wiring diagram" of cell contacts in the animal. Recent years have also brought the first successes in molecularly cloning genes of developmental interest defined only by mutation, using transposon tagging as a generally applicable method for identification of the desired DNA sequences. Reintroduction of cloned DNA sequences into the genome has recently been accomplished. A physical map of the genome has been assembled with a combination of cosmid and YAC genes. This "Book of the Worm" serves as a reference source for C. elegans investigators as well as an introductory monograph for other biologists.

• Format: Paperback
• Language: English
• ISBN: 0879694335
• ISBN13: 9780879694333
• Release Date: January 1988
• Publisher: Cold Spring Harbor Laboratory Press
• Length: 667 Pages
• Weight: 2.04 lbs.
• Dimensions: 1.3" x 6.1" x 9.1"

Customer Reviews

Great Resource!

A must-have for any C. elegans laboratory or any researcher interested in beginning to work with C. elegans.

Reseaching on THE Worm

This is an extraordiany book full of information vital for people who are interested or reseaching on C. elegans. It gives detail information as well as illustrations to help guide neophyte undergraduates/graduates to understand why this worm is used as a model for neuroscience reseach. This book covers the genetics, genome, anatomy, cell lineage, development, nerous system, embryology, etc. of C. elegans in as much detail as one will need to know plus useful references. Highly reccommend this book for people working with this worm in the lab.