The Extracellular Matrix: An Overview

Book Overview

Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling. This volume of the series "Biology of Extracellular Matrix" provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans , microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept that ECM components together with their cell surface receptors can be viewed as intricate nano-devices that allow cells to physically organize their 3-D-environment. Further, the role of the ECM in human disease and pathogenesis is discussed as well as the use of model organisms in elucidating ECM function.

• Format: Hardcover
• Language: English
• ISBN: 3642165540
• ISBN13: 9783642165542
• Release Date: February 2011
• Publisher: Springer
• Length: 426 Pages
• Weight: 1.65 lbs.
• Dimensions: 1.1" x 6.2" x 9.1"