Tgf-β In Human Disease

By Aristidis Moustakas

Book Overview

Part I Introduction.- 1 Transforming Growth Factor-β Signaling.- 2 TGF-β Signaling in Stem Cell Fate Determination.- 3 Emerging Roles of TGF-β Co-receptors in Human Disease.- Part II Cancer, Fibrosis, and Inflammation.- 4 TGF-β in Cancer Stem Cells.- 5 TGF-β as Tumor Suppressor: In Vitro Mechanistic Aspects of Growth Inhibition.- 6 TGF-β as Tumor Suppressor: Lessons from Mouse Models.- 7 The Multifunctional Roles of TGF-β in Navigating the Metastatic Cascade.- 8 TGF-β Signaling in Leukemogenesis.- 9 TGF-β in Skin Cancer and Fibrosis.- 10 The Role of TGF-β in Cutaneous Melanoma Biology.- 11 The Transforming Growth Factor-Beta (TGF-β) in Liver Fibrosis.- 12 TGF-β and Inhibitory Smads in Inflammation.- Part III Cardiovascular Diseases.- 13 TGF-β and Cardiovascular Disorders.- 14 TGF-β Signaling in Physiological and Pathological Angiogenesis.- 15 TGF-β Signaling Pathway and MicroRNAs in Cardiovascular Disease.- Part IV Other Diseases.- 16 TGF-β and Genetic Skeletal Diseases.- 17 TGF-β in Brain Disorders.- 18 TGF-β and Metabolic Homeostasis.- Part V Disease Prognosis and Therapy. 19 Targeting Pro-Angiogenic TGF-β Signaling in the Tumor Microenvironment.

• Format: Paperback
• Language: English
• ISBN: 4431546863
• ISBN13: 9784431546863
• Release Date: July 2015
• Publisher: Springer
• Length: 464 Pages
• Weight: 1.45 lbs.
• Dimensions: 0.9" x 6.1" x 9.2"