Taxane Anticancer Agents: Basic Science and Current Status : Developed from a Symposium Sponsored by the Divisions of Chemical Health and Safety, Me (Acs Symposium Series)
Presents an overview of the development of paclitaxel as an anticancer drug, including the discovery, initial development, current status, supply issues, and recent clinical developments. Discusses in detail the cellular mechanism of action and the toxicity of paclitaxel. Presents drug delivery and taxotere metabolism. Explains semisynthetic and medicinal chemistry studies. Covers approaches to the total synthesis of paclitaxel.
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