Targeted Cancer Treatment in Silico: Small Molecule Inhibitors and Oncolytic Viruses

By Dominik Wodarz and Natalia L. Komarova

Book Overview

Background and Scope of the Book.- Part I Treatment of Cancer with Small Molecule Inhibitors.- An Introduction to Small Molecule Inhibitors and Chronic Myeloid Leukemia.- Basic Dynamics of Chronic Myeloid Leukemia During Imatinib Treatment.- Stochastic Modeling of Cellular Growth, Treatment, and Resistance Generation.- Evolutionary Dynamics of Drug Resistant Mutants in Targeted Treatment of CML.- Effect of Cellular Quiescence on the Evolution of Drug Resistance in CML.- Combination Therapies: Short term versus Long term Strategies.- Cross Resistance: Treatment and Modeling.- Mathematical Modeling of Cyclic Cancer Treatments.- Part II Treatment of Cancer with Oncolytic Viruses.- Introduction to Oncolytic Viruses.- Basic Dynamics of Oncolytic Viruses.- Mitotic Virus Transmission and Immune Responses.- Axiomatic Approaches to Oncolytic Virus Modeling.- Spatial Oncolytic Virus Dynamics.- Oncolytic Viruses and the Eradication of Drug-resistant Tumor Cells.

• Format: Paperback
• Language: English
• ISBN: 1493942492
• ISBN13: 9781493942497
• Release Date: August 2016
• Publisher: Birkhauser
• Length: 227 Pages
• Weight: 0.76 lbs.
• Dimensions: 0.5" x 6.1" x 9.2"