Theater director Caden Cotard finds his life unraveling. He suffers from numerous physical ailments and has been growing increasingly alienated from his wife, Adele, an artist. He hits rock bottom when Adele leaves him for a new life in Berlin, taking their four-year-old daughter Olive with her. After the success of his production of Death of a Salesman, Caden unexpectedly receives a MacArthur Fellowship, which gives him the financial means to pursue his artistic interests. He is determined to use it to create an artistic piece of brutal realism and honesty, something into which he can pour his whole self. Gathering an ensemble cast into an enormous warehouse in Manhattan's Theater District, he directs them in a celebration of the mundane, instructing them to live out their constructed lives. As the mockup inside the warehouse grows increasingly mimetic of the city outside, Caden continues to look for solutions to his personal crises.