Studies on the Synthesis of Fused Primidine Derivatives

By Wesam Shehab

INTRODUCTION Pyrimidine Pyrimidine (1) is the trivial name for 1,3-diazine: two meta oriental CH units in benzene have been replaced by nitrogen atom. Pyrimidine has one axis of symmetry about the C2-C5 axis, it has three different pairs of bond lengths and four different bond angles. Accordingly in 1H and 13C-NMR spectra the 1H and 13C nuclei are found at three different chemical shifts. Biological activity of pyrimidines: Pyrimidine derivatives and heterocyclic annelated pyrimidines continue to attract great interest due to the wide variety of interesting biological activities and therapeutic applications Segal et al., 1962] Cumming et al., 2004] such as anticonvulsant Tripathi et al., 1981], analgesic Pemmsin et al., 1988], antihypertensive Cammito et al., 1990], antipyretic Smith et al., 1964], antiviral Balzarini et al., 2002], anti-inflammatory drugs Nega et al., 1990], bactericidal Mastafanova et al., 1982], fungicidal Zhikhareva et al., 1976]. As well as, they are used in agriculture as pesticides Tetsuo et al., 1987] and plant growth regulators Shishoo and Jain, 1992].

• Format: Paperback
• Language: English
• ISBN: 3330846771
• ISBN13: 9783330846777
• Release Date: October 2019
• Publisher: Noor Publishing
• Length: 52 Pages
• Weight: 0.20 lbs.
• Dimensions: 0.1" x 6.0" x 9.0"