Studies on Naturally Occurring and Synthetic Quinones

By C.P. Pokharna

Many synthetic as well as natural products containing the quinone functionality have displayed useful chemotherapeutic activity. Benzoyl/naphthoyl/thienoyl-1,4-benzoquinones have emerged as potential building blocks for the synthesis of medicinally significant anthracyclinones. Anthracyclinones are valuable drugs in the treatment of certain human cancers. The 1,4-benzoquinones are strong electrophiles in the Diels-Alder reactions with variously substituted 1,3-butadienes. This property of quinones has been of great synthetic value.Encouraged by remarkable achievements in the field of naturally occurring as well as synthetic quinones, a systematic study of quinones including their isolation and synthesis have been undertaken. In the present study isolation of quinones from Tecomellaundulata, synthesis of rhinacanthin-A (a naphthoquinone) from lapachol and a number of benzoyl-1,4-benzoquinones were synthesized which are good precursors for the Diels-Alder reaction with various dienes and therefore, this approach may further be extended to the synthesis of anthracyclinones.

• Format: Paperback
• Language: English
• ISBN: 6202530944
• ISBN13: 9786202530941
• Release Date: April 2020
• Publisher: LAP Lambert Academic Publishing
• Length: 192 Pages
• Weight: 0.64 lbs.
• Dimensions: 0.4" x 6.0" x 9.0"