Studies on Experimental Toxicology and Pharmacology

Book Overview

Part I. Toxicological Mechanisms and Evaluation of Oxidative Stress.- A historical perspective on oxidative stress and intracellular redox control .- An overview of free radicals as causes and consequences of toxicity.- Oxidants, radicals, free radicals, and other bad stuff in mechanisms of toxicity.- Lipid oxidation.- Protein oxidation and toxicology.- Oxidative stress and DNA damage association with carcinogenesis: A truth or a myth?.- Glutathione and thiols .- Reactive oxygen species as initiators and mediators of cellular signaling processes.- Role of oxidative stress in the process of carcinogenesis.- Part II. Agents that produce toxicity - mechanisms and therapeutic interventions.- Isolation of murine adult bone marrow and fetal liver cells for mechanistic assessment of hematotoxicity caused by organic solvents.- Oxidative stress and ethanol toxicity.- Pharmaceutical agents.- Insecticides and herbicides .- Health effects of indoor air pollution due to cooking with biomass fuel.- Outdoor pollutants.- Oxidative Stress and the Inorganic Carcinogens.- UV-induced signaling: Role of reactive oxygen species.- Nanomaterials.- Chemical warfare agents.- Part III. Special topics.- On the biochemistry of antioxidants - current aspects.-Prevention of age-related diseases - Effects of antioxidant supplements.- The neural progenitor cell (NPC) niche in the adult brain provides a target for neurotoxicity - a potential Adverse Outcome Pathway for ROS-induced NPC dysfunction with higher sensitivity during aging..- Oxygen toxicity: From cough to convulsion.- Oxidative stress in reproductive toxicology.- Toxicogenomics-based assessment of xenobiotic-induced oxidative stress.- Aquatic and marine biology.

• Format: Paperback
• Language: English
• ISBN: 331934708X
• ISBN13: 9783319347080
• Release Date: August 2016
• Publisher: Humana
• Length: 498 Pages
• Weight: 1.58 lbs.
• Dimensions: 1.0" x 6.1" x 9.2"