1. Introduction.- 2. Development of NK3R Antagonists with a Labile Functional Group in the Natural Environment.- 3. Development of NK3R Antagonists with a Degradable Scaffold in the Natural Environment: Synthesis and Application of Fused Piperazine Derivatives for Investigation of Degradable Core Motifs.- 4. Development of NK3R Antagonists with a Degradable Scaffold in the Natural Environment: Identification of NK3R Antagonists with a Decomposable Core Structure by Scaffold Hopping.- 5. Conclusion.
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