This volume comprises the presentations made at The Workshop Conference on Statistics in Endocrinology held at Endicott House in Dedham, Massachusetts, December 47, 1967. The workshop was organized to acquaint endocrine investigators with modern experimental design and statistical analysis. It demonstrated the with the artful use of statistical tools the endocrinologist may free himself from many unnecessary constraints and thereby increase the economy and validity of his experiments. Contents:1. Experimental Design:Peter Armitage and Richard D. Remington. 2. Analysis of Variance:W. G. Cochran and C. I. Bliss. 3. Multiple Comparisons:C. W. Dunnett. 4. Continuous-Response Assays:C. Philip Cox. 5. Quantal-Response Assays:Byron W. Brown, Jr. 6. Invalidity in Bioassays:Jerome Cornfield. 7. Covariance Analysis in Bioassay and Related Problems:D. J. Finney. 8. Obtaining Maximal Information from Bioassays:C. W. Emmens. 9. Nonparametric Statistics:I. Richard Savage. 10. Continuous-Variable Experimentation:Harry Smith, Jr. 11. Quantal-Response Variable Experimentation: The Up-and-Down Method:W. J. Dixon. 12. Biomathematics:Murray Eden. 13. Interconversion and Production Rates of Steroids: An Example of Biomathematics:J. F. Tait. 14. Pituitary-Adrenal Feedback: An Example of Biomathematics:Sally B. Fand and Richard P. Spencer. 15. An Introduction to Computers:Edward M. Kaplan and John P. Gilbert. 16. Supplementary Discussion. Supplement: Competitive Protein-Binding AssaysI. Theoretical Aspects.17. Introduction.18. Radioimmunoassays:Rosalyn S. Yalow and Solomon A. Berson. 19. Saturation Assays:R. P. Ekins, G. B. Newman, and J. L. H. O'Riordan. 20. Discussion.II. Statistical Aspects.21. Introduction:Griff T. Ross. 22. A Theoretical Model for Statistical Inference in Isotope Displacement Immunoassay:R. B. McHugh and C. L. Meinert. 23. Statistical Quality Control of Radioimmunoassays:D. Rodbard, P. L. Rayford, and Griff T. Ross. 24. Dose-Response Curves for Radioimmunoassays:C. I. Bliss. 25. Discussion.References. Index.
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