Some novel 1, 4-thiazepine derivatives

By S. Sarveswari

The 1, 4-thiazepine fused derivatives were synthesized by L-proline catalyzed one-pot mechanistic pathway. Though L-proline is being amphoteric molecule with both amine end carboxylic acid end, it worked as an enamine base for the catalysis. We aim to synthesize organic molecules with anti-cancer activity. This protocol provides a synthetic route for the efficient synthesis of 1, 4 -thiazepines. All the synthesized molecules were screened for the cytotoxicity studies. We have screened the synthesized 1, 4-thiazepines against to six cell lines, namely 'Pancreas (PANC1), Renal (ACHN), Colon (HCT116), Non-small cell lung (H460), Lung (CALUl) and Normal breast epithelium (MCF10A)' with two concentration 1μM and 10μM concentration levels.

• Format: Paperback
• Language: English
• ISBN: 6205633957
• ISBN13: 9786205633953
• Release Date: January 2023
• Publisher: LAP Lambert Academic Publishing
• Length: 64 Pages
• Weight: 0.23 lbs.
• Dimensions: 0.1" x 6.0" x 9.0"