NMR spectroscopy: Past to present.- Theory - 3D structural information from NMR, part 1.- Application of NOEs and 3JHH-couplings in 3D structure determination.- Development of NMR experiments for determination of long-range J-coupling constants.- Theory - 3D structural information from NMR, part 2.- Determination of long-range residual dipolar coupling constants.- Chiral alignment media for enantiodiscrimination.- Tensor free RDC calculations.- Overall perspective and conclusions.