Smad Signal Transduction: Smads in Proliferation, Differentiation and Disease

By Peter Dijke

1. Preface: the Smad family; P. ten Dijke and C-H. Heldin. 2. Evolution of Smad proteins; S. Newfeld. 3. Smad signaling in C. elegans; R. Padgett and G. Paterson; 4. Mad signaling in Drosophila; L.Raftery. 5. Delineating the TGF- /Smad-induced cytostatic response; F. Liu. 6. TGF- /Smad signaling in mesenchymal cell differentiation; R. Derynck. 7. Regulation of cell death and survival by Smads; K. Luo. 8. TGF- /Smad signaling in epithelial to mesenchymal transition; A. Moustakas. 9. Functional analysis of Smads through gene ablation in mice; C. Deng. 10. Regulation of Smad activation through endocytic segregation of TGF- receptors; J. Wrana. 11. Nucleocytoplasmic shuttling of Smad proteins; C. Hill. 12. Structural insights into Smad function and specificity; Y. Shi . 13. Regulation of Smad function by phosphorylation; S. Souchelnytskyi. 14. Regulation of Smad function through ubiquitination and sumoylation; X.-H. Feng. 15. Smad co-activators and co-repressors; K. Miyazono. 16. Integration of signaling pathways via Smads and Smad interacting proteins; L. Attisano. 17. Interplay between Smad and MAP kinase signaling pathways; A. Mauviel. 18. Gene expression signatures of TGF- /Smad-induced responses; E. B ttinger. 19. Systems biology approaches to TGF- /Smad signaling; M. Tewari. 20. Inhibitory Smads; mechanism of action and role in human diseases; A. Nakao. 21. Alterations of Smad signaling in carcinogenesis; S.-J. Kimand J. Letterio. 22. TGF- receptor kinase inhibitors for treatment of cancer; J. Yingling. 23. TGF- receptor kinase inhibitors for treatment of fibrosis; N. Laping and S. Huet.

• Format: Paperback
• Language: English
• ISBN: 9048171458
• ISBN13: 9789048171453
• Release Date: November 2010
• Publisher: Springer
• Length: 472 Pages
• Weight: 1.49 lbs.
• Dimensions: 1.0" x 6.1" x 9.2"