Skeletal Biology and Medicine, Part B

This volume highlights new insights into the mechanisms of bonedevelopment, including cellular and mechanical factors, receptors, and signaling pathways and their role in both normative andpathologic states of bone.

The second of two volumes, this volume comprises three sections: (1) new insights on the interaction of blood vessels and bone, particularly the role of angiogenic signals and hypoxia inosteogenesis and bone repair, as well as the dysregulation oftranscription factors causing arterial calcification; (2) a newtheme--integrating the evolving role of immune cells, infection, and inflammation in causing bone loss seen, for example, in various forms of arthritides; and (3) the clinical andtherapeutic challenges in bone, stone, and joint diseases, andareas such as identification of high-risk patients, advent of noveltherapeutic targets, genetic aberrations causing bone disease, andissues surrounding bone loss in malignancy, hyperparathyroidism, and adrenal disorders.

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• Format: Paperback
• Language: English
• ISBN: 1573317284
• ISBN13: 9781573317283
• Release Date: January 2008
• Publisher: Wiley-Blackwell
• Length: 500 Pages