Single-Arm Phase II Survival Trial Design

By Jianrong Wu

Book Overview

Single-Arm Phase II Survival Trial Design provides a comprehensive summary to the most commonly- used methods for single-arm phase II trial design with time-to-event endpoints. Single-arm phase II trials are a key component for successfully developing advanced cancer drugs and treatments, particular for target therapy and immunotherapy in which time-to-event endpoints are often the primary endpoints. Most test statistics for single-arm phase II trial design with time-to-event endpoints are not available in commercial software.

Key Features:

Covers the most frequently used methods for single-arm phase II trial design with time-to-event endpoints in a comprehensive fashion.

Provides new material on phase II immunotherapy trial design and phase II trial design with TTP ratio endpoint.

Illustrates trial designs by real clinical trial examples

Includes R code for all methods proposed in the book, enabling straightforward sample size calculation.

• Format: Paperback
• Language: English
• ISBN: 0367653494
• ISBN13: 9780367653491
• Release Date: July 2023
• Publisher: CRC Press
• Length: 263 Pages
• Weight: 0.85 lbs.
• Dimensions: 0.6" x 6.1" x 9.2"