Simone Gold was born to Reuben Tizes, a medical school professor, and Carol Tizes, an elementary school teacher for special needs children. Raised on Long Island, New York, Gold excelled academically, graduating from the City College of New York at just 19 years old. She went on to earn her Doctor of Medicine (M.D.) degree from the Chicago Medical School in 1989. Despite her father's wishes for her to pursue a career exclusively in medicine, Gold attended Stanford Law School, which she described as her "rebellion." She graduated in 1993 and was admitted to the New York bar in 1997. That same year, she completed a residency in emergency medicine at the Renaissance School of Medicine at Stony Brook University.
Gold claimed to have worked as a fellow for U.S. Congressman Jim Jeffords in 1997 and later as an assistant to Israeli Ambassador to the United States Michael Oren in 2009. However, both figures later stated they had no memory of her involvement.